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Xyzal Allergy 24HR, from Sanofi, contains levocetirizine, an antihistamine previously only available with a prescription Xyzal is an antihistamine that reduces the effects of natural chemical histamine in the body. Xyzal is in a drug class called antihistamines. Try for free *Refers to first dose only yes yes, I am clean from Vicoden, Antidepresants but still am using a sleep aid, have been using over the counter meds for sleep since the 80's then went to prescription sleep aid and now I only sleep 3 or 4 hours using them. Sanofi promotes Xyzal as a mirror. Both are likely to make you less drowsy than alternatives such as Benadryl. Yes, Xyzal Allergy 24HR (oral tablets) and Children's Xyzal Allergy 24HR (liquid) are available over-the-counter (OTC) for treatment of symptoms due to seasonal and year-round allergies. Xyzal was initially approved in 2007 by the FDA as a prescription only medication indicated for the treatment of seasonal and year round allergy symptoms. 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When allergic individuals encounter allergens, their bodies release “histamines. However, you should be aware that potential side effects of Xyzal include sleepiness, nosebleed, fever, sore throat, dry mouth, and cough, although more severe reactions might include swelling, rash and itching. Xyzal and Claritin are over-the-counter medications used to relieve symptoms of allergic rhinitis. Xyzal is produced by Sanofi, and Zyrtec is produced by a division of Johnson & Johnson. I am going to go off them soon Xyzal is produced by Sanofi, and Zyrtec is produced by a division of Johnson & Johnson. I am going to go off them soon As the latest over-the-counter branded oral antihistamine, Xyzal offers effective relief for symptoms of hay fever or other respiratory allergies year-round. In this article, we will discuss everything you want to know about Xyzal OTC! Parents who have additional questions should talk to a pediatrician, allergist, pharmacist or other healthcare provider. 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